EdenteV2, Main, Exploration, bibRecord, 008124

Antibodies to periodontal pathogens are associated with coronary heart disease

Identifieur interne : 008124 ( Main/Exploration ); précédent : 008123; suivant : 008125

Antibodies to periodontal pathogens are associated with coronary heart disease

Auteurs : Pirkko J. Pussinen [Finlande] ; Pekka Jousilahti [Finlande] ; Georg Alfthan [Finlande] ; Timo Palosuo [Finlande] ; Sirkka Asikainen [Finlande, Suède] ; Veikko Salomaa [Finlande]

Source :

Arteriosclerosis, thrombosis, and vascular biology [ 1079-5642 ] ; 2003.

RBID : Pascal:04-0019041

Descripteurs français

Pascal (Inist)
- Cardiopathie coronaire, Homme, Anticorps, Parodontite, Sérologie, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Bactériose, Association morbide, Physiopathologie, Pathogénie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Actinobacillus actinomycetemcomitans, Antibody, Bacteriosis, Concomitant disease, Coronary heart disease, Human, Pathogenesis, Pathophysiology, Periodontitis, Porphyromonas gingivalis, Serology.

Abstract

Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.

Affiliations:

Finlande, Suède

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Le document en format XML

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<series><title level="j" type="main">Arteriosclerosis, thrombosis, and vascular biology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actinobacillus actinomycetemcomitans</term>
<term>Antibody</term>
<term>Bacteriosis</term>
<term>Concomitant disease</term>
<term>Coronary heart disease</term>
<term>Human</term>
<term>Pathogenesis</term>
<term>Pathophysiology</term>
<term>Periodontitis</term>
<term>Porphyromonas gingivalis</term>
<term>Serology</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie coronaire</term>
<term>Homme</term>
<term>Anticorps</term>
<term>Parodontite</term>
<term>Sérologie</term>
<term>Actinobacillus actinomycetemcomitans</term>
<term>Porphyromonas gingivalis</term>
<term>Bactériose</term>
<term>Association morbide</term>
<term>Physiopathologie</term>
<term>Pathogénie</term>
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<front><div type="abstract" xml:lang="en">Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.</div>
</front>
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Antibodies to periodontal pathogens are associated with coronary heart disease

Antibodies to periodontal pathogens are associated with coronary heart disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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